Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
  • Upload

  • Log in

  • Sign up

Search on MyScienceWork
1 News 496 Publications 19 Members

Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic ...

Pang, Hong-Bo Braun, Gary B Ruoslahti, Erkki

Published in Science advances

Cell-penetrating peptides (CPPs) have been widely used to deliver nanomaterials and other types of macromolecules into mammalian cells for therapeutic and diagnostic use. Cationic CPPs that bind to heparan sulfate (HS) proteoglycans on the cell surface induce potent endocytosis; however, the role of other surface receptors in this process is unclea...

Nanoparticles coated with the tumor-penetrating peptide iRGD reduce experimental breast cancer metastasis in the brain

Hamilton, Amanda M. Aidoudi-Ahmed, Sallouha Sharma, Shweta Kotamraju, Venkata R. Foster, Paula J. Sugahara, Kazuki N. Ruoslahti, Erkki Rutt, Brian K.

Published in Journal of Molecular Medicine

AbstractMetastasis is the main killer in cancer; consequently, there is great interest in novel approaches to prevent and treat metastatic disease. Brain metastases are particularly deadly, as the protection of the blood-brain barrier obstructs the passage of common anticancer drugs. This study used magnetic resonance imaging (MRI) to investigate t...

Gated Luminescence Imaging of Silicon Nanoparticles.

Joo, Jinmyoung Liu, Xiangyou Kotamraju, Venkata Ramana Ruoslahti, Erkki Nam, Yoonkey Sailor, Michael J

Published in ACS nano

The luminescence lifetime of nanocrystalline silicon is typically on the order of microseconds, significantly longer than the nanosecond lifetimes exhibited by fluorescent molecules naturally present in cells and tissues. Time-gated imaging, where the image is acquired at a time after termination of an excitation pulse, allows discrimination of a s...

Clot-targeted micellar formulation improves anticoagulation efficacy of bivalirudin.

She, Zhi-Gang Liu, Xiangyou Kotamraju, Venkata R Ruoslahti, Erkki

Published in ACS nano

Application of anticoagulants remains the primary strategy for prevention and treatment of thrombosis. However, high rate of bleeding complications limits their use. The peptide anticoagulant bivalirudin has been reported to exhibit a lower rate of bleeding complications than heparin, and it also has the advantage of not causing thrombocytopenia, w...

(64)Cu-labeled LyP-1-dendrimer for PET-CT imaging of atherosclerotic plaque.

Seo, Jai Woong Baek, Hyounggee Mahakian, Lisa M Kusunose, Jiro Hamzah, Juliana Ruoslahti, Erkki Ferrara, Katherine W

Published in Bioconjugate chemistry

The ability to detect and quantify macrophage accumulation can provide important diagnostic and prognostic information for atherosclerotic plaque. We have previously shown that LyP-1, a cyclic 9-amino acid peptide, binds to p32 proteins on activated macrophages, facilitating the visualization of atherosclerotic plaque with PET. Yet, the in vivo pla...

A Novel Vascular Homing Peptide Strategy to Selectively Enhance Pulmonary Drug Efficacy in Pulmonary Arterial Hypertensi...

Toba, Michie Alzoubi, Abdallah O’Neill, Kealan Abe, Kohtaro Urakami, Takeo Komatsu, Masanobu Alvarez, Diego Järvinen, Tero A.H. Mann, David Ruoslahti, Erkki ...

Published in The American Journal of Pathology

A major limitation in the pharmacological treatment of pulmonary arterial hypertension (PAH) is the lack of pulmonary vascular selectivity. Recent studies have identified a tissue-penetrating homing peptide, CARSKNKDC (CAR), which specifically homes to hypertensive pulmonary arteries but not to normal pulmonary vessels or other tissues. Some tissue...

Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced anti...

Kulkarni, Ashish A Roy, Bhaskar Rao, Poornima S Wyant, Gregory A Mahmoud, Ayaat Ramachandran, Madhumitha Sengupta, Poulomi Goldman, Aaron Kotamraju, Venkata Ramana Basu, Sudipta ...

Published in Cancer research

The centrality of phosphoinositide-3-kinase (PI3K) in cancer etiology is well established, but clinical translation of PI3K inhibitors has been limited by feedback signaling, suboptimal intratumoral concentration, and an insulin resistance "class effect." This study was designed to explore the use of supramolecular nanochemistry for targeting PI3K ...

Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human an...

Sánchez-Martín, David Martínez-Torrecuadrada, Jorge Teesalu, Tambet Sugahara, Kazuki N Alvarez-Cienfuegos, Ana Ximénez-Embún, Pilar Fernández-Periáñez, Rodrigo Martín, M Teresa Molina-Privado, Irene Ruppen-Cañás, Isabel ...

Published in Proceedings of the National Academy of Sciences of the United States of America

Antibody cancer therapies rely on systemically accessible targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor site. Here, we present proof-of-principle of in vivo selection of human antibodies in tumor-bearing mice that identified a tumor-specific antibody able to deliver a payload and unveils the targ...

Bit1 in anoikis resistance and tumor metastasis

S, Jenning T, Pham Sk, Ireland Erkki Ruoslahti H, Biliran

Published in Cancer Letters

Epithelial cells and most adherent normal cells rely on adhesion-dependent, integrin-mediated survival signals from the extracellular matrix (ECM) to survive. When these cells are deprived of adhesion to the ECM, they undergo a specific form of apoptosis termed "anoikis." In contrast, malignant cells have attained mechanisms to enable them to survi...

Engineering strategy to improve peptide analogs: from structure-based computational design to tumor homing

Zanuy, David Sayago, Francisco J. Revilla-López, Guillem Ballano, Gema Agemy, Lilach Kotamraju, Venkata Ramana Jiménez, Ana I. Cativiela, Carlos Nussinov, Ruth Sawvel, April M. ...

Published in Journal of Computer-Aided Molecular Design

We present a chemical strategy to engineer analogs of the tumor-homing peptide CREKA (Cys-Arg-Glu-Lys-Ala), which binds to fibrin and fibrin-associated clotted plasma proteins in tumor vessels (Simberg et al. in Proc Natl Acad Sci USA 104:932–936, 2007) with improved ability to inhibit tumor growth. Computer modeling using a combination of simulate...

  • ← Previous
  • 1 (current)
  • 2
  • 3
  • 4
  • 5
  • …
  • 49
  • Next →
Powered by Polaris
  • About the Lab
  • Our Research
  • About this Platform
  • FAQ