Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
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1 News 496 Publications 19 Members

Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice.

Järvinen, Tero A H Ruoslahti, Erkki

Published in Proceedings of the National Academy of Sciences of the United States of America

Permanent scars form upon healing of tissue injuries such as those caused by ischemia (myocardial infarction, stroke), trauma, surgery, and inflammation. Current options in reducing scar formation are limited to local intervention. We have designed a systemically administered, target-seeking biotherapeutic for scar prevention. It consists of a vasc...

Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion.

G, Malik Lm, Knowles R, Dhir S, Xu S, Yang E, Ruoslahti J, Pilch

Published in Cancer Research

The attachment of circulating tumor cells to the blood vessels of distant organs is an important step in metastasis. We show here that experimental lung metastasis by two cell lines, B16F1 melanoma and 3LL lung carcinoma, is greatly reduced in transgenic mice that lack plasma fibronectin. This multifunctional adhesive glycoprotein becomes cross-lin...

Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery

Ji Ho Park G, Von Maltzahn Ll, Ong A, Centrone Ta, Hatton Erkki Ruoslahti Sn, Bhatia Mj, Sailor

Published in Advanced Materials

Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation

Valentina Fogal Ad, Richardson Priya Karmali Ie, Scheffler Jw, Smith Erkki Ruoslahti

Published in Molecular and Cellular Biology

p32/gC1qR/C1QBP/HABP1 is a mitochondrial/cell surface protein overexpressed in certain cancer cells. Here we show that knocking down p32 expression in human cancer cells strongly shifts their metabolism from oxidative phosphorylation (OXPHOS) to glycolysis. The p32 knockdown cells exhibited reduced synthesis of the mitochondrial-DNA-encoded OXPHOS ...

Cooperative nanomaterial system to sensitize, target, and treat tumors.

Jh, Park G, Von Maltzahn Mj, Xu V, Fogal Vr, Kotamraju E, Ruoslahti Sn, Bhatia Mj, Sailor

Published in Proceedings of the National Academy of Sciences

A significant barrier to the clinical translation of systemically administered therapeutic nanoparticles is their tendency to be removed from circulation by the mononuclear phagocyte system. The addition of a targeting ligand that selectively interacts with cancer cells can improve the therapeutic efficacy of nanomaterials, although these systems h...

Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo.

Simberg, Dmitri Zhang, Wan-Ming Merkulov, Sergei McCrae, Keith Park, Ji-Ho Sailor, Michael J Ruoslahti, Erkki

Published in Journal of controlled release : official journal of the Controlled Release Society

Previously we reported that plasma kallikrein and high molecular weight kininogen attach to the surface of dextran-coated superparamagnetic iron oxide nanoparticles (SPION) through the incompletely covered iron oxide core (Simberg et al., Biomaterials, 2009). Here we show that SPION also activate kallikrein-kinin system in vitro and in vivo. The se...

Tissue-penetrating delivery of compounds and nanoparticles into tumors.

Kn, Sugahara T, Teesalu Pp, Karmali Vr, Kotamraju L, Agemy Om, Girard D, Hanahan Rf, Mattrey E, Ruoslahti

Published in Cancer Cell International

Poor penetration of drugs into tumors is a major obstacle in tumor treatment. We describe a strategy for peptide-mediated delivery of compounds deep into the tumor parenchyma that uses a tumor-homing peptide, iRGD (CRGDK/RGPD/EC). Intravenously injected compounds coupled to iRGD bound to tumor vessels and spread into the extravascular tumor parench...

Effect of the lipid chain melting transition on the stability of DSPE-PEG(2000) micelles.

M, Kastantin B, Ananthanarayanan P, Karmali E, Ruoslahti M, Tirrell

Published in Langmuir

Micellar nanoparticles are showing promise as carriers of diagnostic and therapeutic biofunctionality, leading to increased interest in their properties and behavior, particularly their size, shape, and stability. This work investigates the physical chemistry of micelles formed from DSPE-PEG(2000) monomers as it pertains to these properties. A melt...

In silico molecular engineering for a targeted replacement in a tumor-homing peptide.

D, Zanuy A, Flores-Ortega Ai, Jiménez Mi, Calaza C, Cativiela R, Nussinov E, Ruoslahti C, Alemán

Published in The Journal of Physical Chemistry B

A new amino acid has been designed as a replacement for arginine (Arg, R) to protect the tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) from proteases. This amino acid, denoted (Pro)hArg, is characterized by a proline skeleton bearing a specifically oriented guanidinium side chain. This residue combines the ability of Pro to induce turn-like...

Targeting atherosclerosis by using modular, multifunctional micelles

Peters, David Kastantin, Mark Kotamraju, Venkata Ramana Karmali, Priya P. Gujraty, Kunal Tirrell, Matthew Ruoslahti, Erkki

Published in Proceedings of the National Academy of Sciences of the United States of America

Subtle clotting that occurs on the luminal surface of atherosclerotic plaques presents a novel target for nanoparticle-based diagnostics and therapeutics. We have developed modular multifunctional micelles that contain a targeting element, a fluorophore, and, when desired, a drug component in the same particle. Targeting atherosclerotic plaques in ...

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