Alpha fetoprotein in uterine hemorrhage during pregnancy and delivery.
Published in American Journal of Obstetrics and Gynecology
Regulation of the fibronectin receptor affinity by divalent cations.
Published in Journal of Biological Chemistry
The cell surface receptor for fibronectin is a heterodimeric membrane protein that recognizes an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for binding to fibronectin. The divalent cation requirements of this receptor were analyzed by measuring attachment of receptor liposomes to ligand-coated surfaces in the...
A fibronectin self-assembly site involved in fibronectin matrix assembly: reconstruction in a synthetic peptide.
Published in The Journal of Cell Biology
The active form of fibronectin is its extracellular matrix form, which allows for the attachment of cells and influences both the growth and migration of cells. The matrix form is assembled by cells; however, many cells are defective in this regard. Several regions within fibronectin have been shown to play a role in matrix assembly by cells. One s...
Differentiation of fetal liver cells in vitro.
Published in Proceedings of the National Academy of Sciences
Fetal mouse liver hepatocytes proliferate on a substrate of irradiated pigskin epidermis scored with scalpel blade slits to permit cell access to the basement membrane. At the time the cells are explanted, fetal genes, such as those responsible for production of alpha-fetoprotein (AFP) and gamma-glutamyltransferase (GGTase), are strongly expressed....
Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases.
Published in Journal of Controlled Release
As a general strategy to selectively target antibody activity in vivo, a molecular architecture was designed to render binding activity dependent upon proteases in disease tissues. A protease-activated antibody (pro-antibody) targeting vascular cell adhesion molecule 1 (VCAM-1), a marker of atherosclerotic plaques, was constructed by tethering a bi...
Affinity of IgM and IgG antibodies.
Published in Immunochemistry
The RGD story: a personal account.
Published in Matrix Biology
Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression.
Published in The Journal of Cell Biology
Adherent cells assemble fibronectin into a fibrillar matrix on their apical surface. The fibril formation is initiated by fibronectin binding to the integrins alpha5 beta1 and alphav beta3, and is completed by a process that includes fibronectin self-assembly. We found that a 76- amino acid fragment of fibronectin (III1-C) that forms one of the sel...
Fibronectin and its receptors.
Published in Annual Review of Biochemistry
