Versatile mechanisms of cell adhesion.
Published in Harvey lectures
Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
Published in Cell
Affinity chromatography was used to identify a putative cell surface receptor for fibronectin. A large cell-attachment-promoting fibronectin fragment was used as the affinity matrix, and specific elution was effected by using synthetic peptides containing the sequence Arg-Gly-Asp, which is derived from the cell recognition sequence in the fibronect...
Fibronectin: purification, immunochemical properties, and biological activities
Published in G Protein Coupled Receptors - Structure
Binding of fibronectin to actin is inhibited by gelatin
Published in Biochemical and Biophysical Research Communications
Brain extracellular matrix.
Published in Glycobiology
The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant. Matrix proteins common in other tissu...
The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by pr...
Published in Proceedings of the National Academy of Sciences
The lecticans are a family of chondroitin sulfate proteoglycans including aggrecan, versican, neurocan, and brevican. The C-terminal globular domains of lecticans are structurally related to selectins, consisting of a C-type lectin domain flanked by epidermal growth factor and complement regulatory protein domains. The C-type lectin domain of versi...
Molecular cloning and sequence analysis of a chondroitin sulfate proteoglycan cDNA.
Published in Proceedings of the National Academy of Sciences
We report the identification and DNA sequence of a chondroitin sulfate proteoglycan core protein cDNA. A cDNA clone, pPG1, was selected from a rat yolk sac tumor poly(A)+RNA-derived cDNA library by using synthetic oligonucleotides predicted from the NH2-terminal peptide sequence of the mature chondroitin sulfate proteoglycan. The resulting sequence...
Specialization of tumour vasculature.
Published in Nat Rev Cancer
Tumour blood vessels express markers that are not present in resting blood vessels of normal tissues, but that can be shared by angiogenic vessels in non-malignant conditions. Many of these proteins are functionally important in the angiogenic process. Some tumours also contain lymphatic vessels, as well as channels that consist of cancer cells and...
Fibronectin: current concepts of its structure and functions.
Published in Collagen and Related Research
Isolation of a chondroitin sulfate proteoglycan from a rat yolk sac tumor and immunochemical demonstration of its cell s...
Published in Journal of Biological Chemistry
A proteoglycan was isolated from ascites fluid produced by a rat yolk sac tumor. The glycosaminoglycan chains of the proteoglycan are all sensitive to digestion with chondroitinase ABC and about 90% are sensitive to chondroitinase AC. The proteoglycan contains 5% protein. Amino acid analysis revealed a high content of serine and glycine which toget...
