Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
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1 News 496 Publications 19 Members

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1

Wa, Border S, Okuda Lr, Languino Mb, Sporn Erkki Ruoslahti

Published in Nature

Glomerulonephritis is an inflammation of the kidney characterized by the accumulation of extracellular matrix within the damaged glomeruli, impaired filtration and proteinuria. In its progressive form, the disease destroys kidney function leading to uraemia and death, unless dialysis therapy or kidney transplantation is available. The pathogenesis ...

Versatile mechanisms of cell adhesion.

Erkki Ruoslahti

Published in Harvey lectures

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor

R, Pytela Md, Pierschbacher Erkki Ruoslahti

Published in Cell

Affinity chromatography was used to identify a putative cell surface receptor for fibronectin. A large cell-attachment-promoting fibronectin fragment was used as the affinity matrix, and specific elution was effected by using synthetic peptides containing the sequence Arg-Gly-Asp, which is derived from the cell recognition sequence in the fibronect...

Fibronectin: purification, immunochemical properties, and biological activities

M, Pierschbacher E, Engvall Erkki Ruoslahti Eg, Hayman

Published in G Protein Coupled Receptors - Structure

Binding of fibronectin to actin is inhibited by gelatin

J, Keski-Oja Erkki Ruoslahti E, Engvall

Published in Biochemical and Biophysical Research Communications

Brain extracellular matrix.

Erkki Ruoslahti

Published in Glycobiology

The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant. Matrix proteins common in other tissu...

The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by pr...

Aspberg, A Miura, R Bourdoulous, S Shimonaka, M Heinegârd, D Schachner, M Erkki Ruoslahti Yamaguchi, Y

Published in Proceedings of the National Academy of Sciences

The lecticans are a family of chondroitin sulfate proteoglycans including aggrecan, versican, neurocan, and brevican. The C-terminal globular domains of lecticans are structurally related to selectins, consisting of a C-type lectin domain flanked by epidermal growth factor and complement regulatory protein domains. The C-type lectin domain of versi...

Molecular cloning and sequence analysis of a chondroitin sulfate proteoglycan cDNA.

Bourdon, Ma Oldberg, A Pierschbacher, M Erkki Ruoslahti

Published in Proceedings of the National Academy of Sciences

We report the identification and DNA sequence of a chondroitin sulfate proteoglycan core protein cDNA. A cDNA clone, pPG1, was selected from a rat yolk sac tumor poly(A)+RNA-derived cDNA library by using synthetic oligonucleotides predicted from the NH2-terminal peptide sequence of the mature chondroitin sulfate proteoglycan. The resulting sequence...

Specialization of tumour vasculature.

Erkki Ruoslahti

Published in Nat Rev Cancer

Tumour blood vessels express markers that are not present in resting blood vessels of normal tissues, but that can be shared by angiogenic vessels in non-malignant conditions. Many of these proteins are functionally important in the angiogenic process. Some tumours also contain lymphatic vessels, as well as channels that consist of cancer cells and...

Fibronectin: current concepts of its structure and functions.

Erkki Ruoslahti Engvall, E Hayman, Eg

Published in Collagen and Related Research

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