Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
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Bit1 in anoikis resistance and tumor metastasis

S, Jenning T, Pham Sk, Ireland Erkki Ruoslahti H, Biliran

Published in Cancer Letters

Epithelial cells and most adherent normal cells rely on adhesion-dependent, integrin-mediated survival signals from the extracellular matrix (ECM) to survive. When these cells are deprived of adhesion to the ECM, they undergo a specific form of apoptosis termed "anoikis." In contrast, malignant cells have attained mechanisms to enable them to survi...

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