Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
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Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo.

Simberg, Dmitri Zhang, Wan-Ming Merkulov, Sergei McCrae, Keith Park, Ji-Ho Sailor, Michael J Ruoslahti, Erkki

Published in Journal of controlled release : official journal of the Controlled Release Society

Previously we reported that plasma kallikrein and high molecular weight kininogen attach to the surface of dextran-coated superparamagnetic iron oxide nanoparticles (SPION) through the incompletely covered iron oxide core (Simberg et al., Biomaterials, 2009). Here we show that SPION also activate kallikrein-kinin system in vitro and in vivo. The se...

A tumor-penetrating peptide enhances circulation-independent targeting of peritoneal carcinomatosis.

Kazuki Sugahara Scodeller, P Gary Braun De Mendoza, Th Yamazaki, Cm Kluger, Md Kitayama, J Alvarez, E Howell, Sb Tambet Teesalu ...

Published in Journal of Controlled Release

Peritoneal carcinomatosis is a major source of morbidity and mortality in patients with advanced abdominal neoplasms. Intraperitoneal chemotherapy (IPC) is an area of intense interest given its efficacy in ovarian cancer. However, IPC suffers from poor drug penetration into peritoneal tumors. As such, extensive cytoreductive surgery is required pri...

A free cysteine prolongs the half-life of a homing peptide and improves its tumor-penetrating activity

Pang, Hong-Bo Braun, Gary B. She, Zhi-Gang Kotamraju, Venkata R. Sugahara, Kazuki N. Teesalu, Tambet Ruoslahti, Erkki

Published in Journal of Controlled Release

Urokinase-controlled tumor penetrating peptide.

Gary Braun Kazuki Sugahara Yu, Om V. Ramana Kotamraju Mölder, T Lowy, Am Erkki Ruoslahti Tambet Teesalu

Published in Journal of Controlled Release

Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases.

Erster, O Thomas, Jm Hamzah, J Jabaiah, Am Getz, Ja Schoep, Td Hall, Ss Erkki Ruoslahti Daugherty, Ps

Published in Journal of Controlled Release

As a general strategy to selectively target antibody activity in vivo, a molecular architecture was designed to render binding activity dependent upon proteases in disease tissues. A protease-activated antibody (pro-antibody) targeting vascular cell adhesion molecule 1 (VCAM-1), a marker of atherosclerotic plaques, was constructed by tethering a bi...

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