Simberg, Dmitri Zhang, Wan-Ming Merkulov, Sergei McCrae, Keith Park, Ji-Ho Sailor, Michael J Ruoslahti, Erkki
Published in
Journal of controlled release : official journal of the Controlled Release Society
Previously we reported that plasma kallikrein and high molecular weight kininogen attach to the surface of dextran-coated superparamagnetic iron oxide nanoparticles (SPION) through the incompletely covered iron oxide core (Simberg et al., Biomaterials, 2009). Here we show that SPION also activate kallikrein-kinin system in vitro and in vivo. The se...
Kazuki Sugahara Scodeller, P Gary Braun De Mendoza, Th Yamazaki, Cm Kluger, Md Kitayama, J Alvarez, E Howell, Sb Tambet Teesalu
...
Published in
Journal of Controlled Release
Peritoneal carcinomatosis is a major source of morbidity and mortality in patients with advanced abdominal neoplasms. Intraperitoneal chemotherapy (IPC) is an area of intense interest given its efficacy in ovarian cancer. However, IPC suffers from poor drug penetration into peritoneal tumors. As such, extensive cytoreductive surgery is required pri...
Erster, O Thomas, Jm Hamzah, J Jabaiah, Am Getz, Ja Schoep, Td Hall, Ss Erkki Ruoslahti Daugherty, Ps
Published in
Journal of Controlled Release
As a general strategy to selectively target antibody activity in vivo, a molecular architecture was designed to render binding activity dependent upon proteases in disease tissues. A protease-activated antibody (pro-antibody) targeting vascular cell adhesion molecule 1 (VCAM-1), a marker of atherosclerotic plaques, was constructed by tethering a bi...
