Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
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Mapping of Vascular ZIP Codes by Phage Display

Teesalu, Tambet Sugahara, Kazuki N. Ruoslahti, Erkki

Published in Methods in Enzymology

Each organ and pathology has a unique vascular ZIP code that can be targeted with affinity ligands. In vivo peptide phage display can be used for unbiased mapping of the vascular diversity. Remarkably, some of the peptides identified by such screens not only bind to target vessels but also elicit biological responses. Recently identified tissue-pen...

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