Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham

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Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation

Valentina Fogal Ad, Richardson Priya Karmali Ie, Scheffler Jw, Smith Erkki Ruoslahti

Published in Molecular and Cellular Biology

p32/gC1qR/C1QBP/HABP1 is a mitochondrial/cell surface protein overexpressed in certain cancer cells. Here we show that knocking down p32 expression in human cancer cells strongly shifts their metabolism from oxidative phosphorylation (OXPHOS) to glycolysis. The p32 knockdown cells exhibited reduced synthesis of the mitochondrial-DNA-encoded OXPHOS ...

Gene expression of the chondroitin sulfate proteoglycan core protein PG19.

Bourdon, Ma Shiga, M Erkki Ruoslahti

Published in Molecular and Cellular Biology

We have examined genomic sequences and mRNA species hybridizing to a cDNA clone of a yolk sac carcinoma chondroitin sulfate proteoglycan designated PG19. Genomic blot hybridizations with cDNAs covering the majority of the PG19 mRNA sequence revealed 15 to 17 gene fragments. Similar analysis with probes representing either the propeptide or the comb...

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases....

Vuori, K Hirai, H Aizawa, S Erkki Ruoslahti

Published in Molecular and Cellular Biology

Integrin-mediated cell adhesion triggers intracellular signaling cascades, including tyrosine phosphorylation of intracellular proteins. Among these are the focal adhesion proteins p130cas (Cas) and focal adhesion kinase (FAK). Here we identify the kinase(s) mediating integrin-induced Cas phosphorylation and characterize protein-protein interaction...

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