TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells.
Published in Molecular cancer research : MCR
TLE1 is a Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer. In the present study, we found that TLE1 is a regulator of anoikis in normal mammary epithelial and breast carcinoma cells. The induction of apoptosis followin...
