Pasqualini, R Erkki Ruoslahti
Published in
Nature
Preferential homing of tumour cells and leukocytes to specific organs indicates that tissues carry unique marker molecules accessible to circulating cells. Organ-selective address molecules on endothelial surfaces have been identified for lymphocyte homing to various lymphoid organs and to tissues undergoing inflammation, and an endothelial marker ...
Erkki Ruoslahti Terry, Wd
Published in
Nature
Attardi, B Erkki Ruoslahti
Published in
Nature
Erkki Ruoslahti Vaheri, A
Published in
Nature
Morla, A Zhang, Z Erkki Ruoslahti
Published in
Nature
Fibronectin is an extracellular matrix protein that is important in development, wound healing and tumorigenesis. In the blood it is dimeric, but in tissues forms disulphide crosslinked fibrils. Here we show that a fragment from the first type-III repeat of fibronectin binds to fibronectin and induces spontaneous disulphide crosslinking of the mole...
Erkki Ruoslahti Seppälä, Ij Simons, K Seppälä, M
Published in
Nature
Wa, Border S, Okuda Lr, Languino Mb, Sporn Erkki Ruoslahti
Published in
Nature
Glomerulonephritis is an inflammation of the kidney characterized by the accumulation of extracellular matrix within the damaged glomeruli, impaired filtration and proteinuria. In its progressive form, the disease destroys kidney function leading to uraemia and death, unless dialysis therapy or kidney transplantation is available. The pathogenesis ...
Border, Wa Noble, Na Yamamoto, T Harper, Jr Yamaguchi, Yu Pierschbacher, Md Erkki Ruoslahti
Published in
Nature
The central pathological feature of human kidney disease that leads to kidney failure is the accumulation of extracellular matrix in glomeruli. Overexpression of transforming growth factor-beta (TGF-beta) underlies the accumulation of pathological matrix in experimental glomerulonephritis. Administration of an antibody raised against TGF-beta to gl...
Erkki Ruoslahti Wigzell, H
Published in
Nature
Yamaguchi, Y Mann, Dm Erkki Ruoslahti
Published in
Nature
Decorin is a small chondroitin-dermatan sulphate proteoglycan consisting of a core protein and a single glycosaminoglycan chain. Eighty per cent of the core protein consists of 10 repeats of a leucin-rich sequence of 24 amino acids. Similar repeats have been found in two other proteoglycans, biglycan and fibromodulin, and in several other proteins ...