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Organ targeting in vivo using phage display peptide libraries.

Published in Nature

Preferential homing of tumour cells and leukocytes to specific organs indicates that tissues carry unique marker molecules accessible to circulating cells. Organ-selective address molecules on endothelial surfaces have been identified for lymphocyte homing to various lymphoid organs and to tissues undergoing inflammation, and an endothelial marker ...

alpha foetoprotein and serum albumin show sequence homology.

Published in Nature

Foetoneonatal oestradiol-binding protein in mouse brain cytosol is alpha foetoprotein.

Published in Nature

Novel human serum protein from fibroblast plasma membrane.

Published in Nature

Superfibronectin is a functionally distinct form of fibronectin.

Published in Nature

Fibronectin is an extracellular matrix protein that is important in development, wound healing and tumorigenesis. In the blood it is dimeric, but in tissues forms disulphide crosslinked fibrils. Here we show that a fragment from the first type-III repeat of fibronectin binds to fibronectin and induces spontaneous disulphide crosslinking of the mole...

Identity of transferrin DChi from the Chinese and from the Finns.

Published in Nature

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1

Published in Nature

Glomerulonephritis is an inflammation of the kidney characterized by the accumulation of extracellular matrix within the damaged glomeruli, impaired filtration and proteinuria. In its progressive form, the disease destroys kidney function leading to uraemia and death, unless dialysis therapy or kidney transplantation is available. The pathogenesis ...

Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease.

Published in Nature

The central pathological feature of human kidney disease that leads to kidney failure is the accumulation of extracellular matrix in glomeruli. Overexpression of transforming growth factor-beta (TGF-beta) underlies the accumulation of pathological matrix in experimental glomerulonephritis. Administration of an antibody raised against TGF-beta to gl...

Breakage of tolerance to alpha foetoprotein in monkeys.

Published in Nature

Negative regulation of transforming growth factor-beta by the proteoglycan decorin.

Published in Nature

Decorin is a small chondroitin-dermatan sulphate proteoglycan consisting of a core protein and a single glycosaminoglycan chain. Eighty per cent of the core protein consists of 10 repeats of a leucin-rich sequence of 24 amino acids. Similar repeats have been found in two other proteoglycans, biglycan and fibromodulin, and in several other proteins ...