Peters, David Kastantin, Mark Kotamraju, Venkata Ramana Karmali, Priya P. Gujraty, Kunal Tirrell, Matthew Ruoslahti, Erkki
Published in
Proceedings of the National Academy of Sciences of the United States of America
Subtle clotting that occurs on the luminal surface of atherosclerotic plaques presents a novel target for nanoparticle-based diagnostics and therapeutics. We have developed modular multifunctional micelles that contain a targeting element, a fluorophore, and, when desired, a drug component in the same particle. Targeting atherosclerotic plaques in ...
Jh, Park G, Von Maltzahn Mj, Xu V, Fogal Vr, Kotamraju E, Ruoslahti Sn, Bhatia Mj, Sailor
Published in
Proceedings of the National Academy of Sciences
A significant barrier to the clinical translation of systemically administered therapeutic nanoparticles is their tendency to be removed from circulation by the mononuclear phagocyte system. The addition of a targeting ligand that selectively interacts with cancer cells can improve the therapeutic efficacy of nanomaterials, although these systems h...
R, Kairouz-Wahbe H, Biliran X, Luo I, Khor M, Wankell C, Besch-Williford J, Pascual R, Oshima E, Ruoslahti
Published in
Proceedings of the National Academy of Sciences
Bcl-2 inhibitor of transcription (Bit1) is a mitochondrial protein that functions as a peptidyl-tRNA hydrolase, but, when released into the cytoplasm, it elicits apoptosis. The proapoptotic function is uniquely counteracted by integrin-mediated cell attachment. We generated a conditional KO mouse of the Bit1 gene by using the Cre-LoxP recombination...
Sánchez-Martín, David Martínez-Torrecuadrada, Jorge Teesalu, Tambet Sugahara, Kazuki N Alvarez-Cienfuegos, Ana Ximénez-Embún, Pilar Fernández-Periáñez, Rodrigo Martín, M Teresa Molina-Privado, Irene Ruppen-Cañás, Isabel
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Antibody cancer therapies rely on systemically accessible targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor site. Here, we present proof-of-principle of in vivo selection of human antibodies in tumor-bearing mice that identified a tumor-specific antibody able to deliver a payload and unveils the targ...
Järvinen, Tero A H Ruoslahti, Erkki
Published in
Proceedings of the National Academy of Sciences of the United States of America
Permanent scars form upon healing of tissue injuries such as those caused by ischemia (myocardial infarction, stroke), trauma, surgery, and inflammation. Current options in reducing scar formation are limited to local intervention. We have designed a systemically administered, target-seeking biotherapeutic for scar prevention. It consists of a vasc...
Yang, Ying-Hua Rajaiah, Rajesh Ruoslahti, Erkki Moudgil, Kamal D
Published in
Proceedings of the National Academy of Sciences of the United States of America
Autoimmune diseases, such as rheumatoid arthritis, frequently target one major tissue/organ despite the systemic nature of the immune response. This is particularly perplexing in the case of ubiquitously distributed antigens invoked in arthritis induction. We reasoned that selective targeting of the synovial joints in autoimmune arthritis might be ...
