Vascular histomolecular analysis by sequential endoarterial biopsy in a shunt model of pulmonary hypertension.
Published in Pulmonary circulation
The molecular mechanisms of pulmonary arterial hypertension (PAH) remain ill-defined. The aims of this study were to obtain sequential endoarterial biopsy samples in a surgical porcine model of PAH and assess changes in histology and mRNA expression during the disease progression. Differentially expressed genes were then analyzed as potential pharm...
