Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
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Vascular histomolecular analysis by sequential endoarterial biopsy in a shunt model of pulmonary hypertension. PDF available through Get Fulltext Research

Rothman, Abraham Davidson, Stephanie Wiencek, Robert G Evans, William N Restrepo, Humberto Sarukhanov, Valeri Ruoslahti, Erkki Williams, Roy Mann, David

Published in Pulmonary circulation

The molecular mechanisms of pulmonary arterial hypertension (PAH) remain ill-defined. The aims of this study were to obtain sequential endoarterial biopsy samples in a surgical porcine model of PAH and assess changes in histology and mRNA expression during the disease progression. Differentially expressed genes were then analyzed as potential pharm...

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