Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
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Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic ...

Pang, Hong-Bo Braun, Gary B Ruoslahti, Erkki

Published in Science advances

Cell-penetrating peptides (CPPs) have been widely used to deliver nanomaterials and other types of macromolecules into mammalian cells for therapeutic and diagnostic use. Cationic CPPs that bind to heparan sulfate (HS) proteoglycans on the cell surface induce potent endocytosis; however, the role of other surface receptors in this process is unclea...

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