Ruoslahti Research Laboratories at UC Santa Barbara and Sanford-Burnham
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Subtypes of human ABO blood groups and subtype-specific antibodies.

Mäkelä, O Erkki Ruoslahti Ehnholm, C

Published in The Journal of Immunology

Unfolded transferrin polypeptide chain is immunologically crossreactive with similar derivatives of serum albumin and al...

Pekkala-Flagan, A Erkki Ruoslahti

Published in The Journal of Immunology

Radioimmunoassays utilizing reduced and carboxymethylated (RC) proteins as antigens reveal a cross-reactivity between alpha-fetoprotein (AFP) and albumin. Similar assays were used to study the relationships of AFP and albumin to other serum proteins. Of the several serum proteins tested, transferrin showed the most similarity with AFP and albumin. ...

Immunochromatography on insolubilized antibodies of very low affinity: application to immunoadsorbence of bovine alpha-f...

Erkki Ruoslahti

Published in The Journal of Immunology

Cross-reactive antibodies were utilized to prepare immunoadsorbents possessing a very low affinity to bovine alpha-fetoprotein (AFP). A goat anti-human AFP serum cross-reactive with bovine AFP was first depleted of antibodies reactive with bovine AFP in immunodiffusion. The remaining antibodies from this serum and gamma-globulin from a sheep antise...

Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes

Mc, Tellier G, Greco M, Klotman A, Mosoian A, Cara W, Arap Erkki Ruoslahti R, Pasqualini Lm, Schnapp

Published in The Journal of Immunology

The ability of viruses and bacteria to interact with the extracellular matrix plays an important role in their infectivity and pathogenicity. Fibronectin is a major component of the extracellular matrix in lymph node tissue, the main site of HIV deposition and replication during the chronic phase of infection. Therefore, we asked whether matrix fib...

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